Other Photoshop Performance Lagging

So, i updated my machine last year purposely for a work machine.

I'm a web developer and work a lot in photoshop & dreamweaver along with various other apps but I have been coming across an annoying slowdown when in both Photoshop and Dreamweaver. Within photoshop it's pretty random but

I understand i'm being a bit vague with this but any suggestions would be apprecited.

Here's my current setup;

PROCESSOR: i7 8700k @ 4.8Ghz All Core on AIO
RAM: 16GB 3000 Ram
GFX: MSI GTX 750 TI
HDD: 1x 500GB M.2, 1x 500GB SATA SSD, 2x 3TB 7200 HDD
NETWORK: WIRED

 

Are you using scratch disks in Photoshop? If so, which disk is it using?

 

Scratch disk is active, however, only the C: Drive (m.2) is in use.