Much has been said here already, but Toploaded, what keyboard and mouse are you looking at? If you are using it for a lot of typing you might want to take a look here (Mechanical keyboards, though they are more expensive and harder to come by) I agree with the i7-930, S-ips monitor, 5870 (maybe later in crossfire) as mentioned before. If I were to buy a motherboard now I would try to get one with USB 3.0, it has some advantages especially for external harddrives. Near sata speeds. But as far as I can remember there are no motherboards yet with a built-in controller, they are all add-in cards. (correct me if I'm wrong) An SSD would be my choice too. I've got a 60GB Vertex and just the difference in responsiveness of the system is amazing. Now you could get a single 250GB SSD, or go for the slightly faster option of two 125GB ones in Raid0. Same size, faster speeds. Use a large 1-2TB hdd on the side like maybe Samsung F3, or the enterprise class drive the WD RE-4 GP 2TB. It has some extra features, is fairly quiet but still quick enough. Or maybe the WD Caviar Black 2TB. For some extra safety you could put two or more in a Raid1 configuration for more redundancy, but you lose some capacity.