I plumped for Francine. Lois' voice would eventually get on my wick, plus I wouldn't want to be where the fat man had been before me, and I can't compete with Gene Simmons' tongue.
Amy Wong all the way! Lois and Marge are in their late 40s, which places them in the same generation as my parents. Call me ageist, but...
After a brief image search, I'm embarrassed to associate myself with Futurama's fanbase: Still...it makes the point, I think. Om nom nom.