That is the question? Personally I've always inverted mouse Y-axis as it felt more natural. This got me pondering... how many of the splendid Bit-Tech folk invert their mouse when gaming? My reasoning is that if I were to place my hand on my head (palm on the crown, fingers towards my forehead) pulling back to look up, pushing forward to look down. Much like how you'd operate a flight stick. In some games, I also re-map my key config from WASD to up/down/left/right because the space around the keys means I don't accidentally eject from a vehicle by hitting E by mistake! How do you play yours?