My story is similar to Joe's in that I used the arrowkeys for years when I was younger, in the Quake/Duke3D era, for the same reasons, but my situation changed over time. I'm right-handed, but my father was forced into left-handedness by a serious injury to his right hand in his early 20s, so our computer desks at home were always built to be left-handed and I grew up using the mouse in my left hand during my 'formative gaming years'. I quickly got used to mouselooking, but I still used arrowkeys for movement with my right hand even when I got my own computer & desk, and I remember doing so right up to about the time I was playing Jedi Knight 2 : Jedi Outcast. I used to have my force powers bound to the ins/home/pgup/del/end/pgdn keys and would use those for Gunsmith-like ninja gameplay back then with easy access. Then one day I think I got sick of rebinding keys in shooters to my left-handed controls and decided to put the mouse in my right hand switch to WASD. At first I found it really annoying, because it meant remapping the force powers in JO to awkward-feeling letter-keys around WASD like Q, E, R, etc. but I got used to it over time. The upside of it is that these days I'm comfortably ambidextrous with the mouse & keyboard. I can switch between them happily as needed. These days, I play WoW with complex keybinds for PvP and the like, with nearly every key using modifiers (via macros with shift, ctrl, alt) for alternate actions. On my Death Knight for instance this is my current setup: WASD = Movement 1-5 = Main Attacks 6-0 = Other convenient abilities Q = Utility cooldowns (Blood Tap, ERW, etc ) Z = PvP Trinket X = Sit (Important for RP ) E = Defensive cooldowns C = Runic Power attacks R = Snares, Grips, Taunts F = Self-heals V = Interrupts/Silences T = Pestilence G = Extra spec-specific cooldowns (Vamp Blood, etc ) B = Minion summons H = Presences N = Presences (Alternate) And that configuration carries over to similar/comparable abilities on my other characters, though it tends to be more complex on my Warlock! In shooters these days I use a fairly typical WASD configuration, though for a long time (prior to HL2, or thereabouts) I kept crouch on left-shift and sprint/run on ctrl. I usually stick 'Reload' on MOUSE4 as I find the 4th button very handy to reach on my MX518 (but Mouse5 never gets used, ever) and I usually bind Melee attacks to R on the keyboard instead, which I think is a holdover from the first shooter with melee attacks that I actually played significantly, which was F.E.A.R. It's interesting to see how much people vary in their preferences with these things!