This is driving me mad. I run Windows 7 Pro 64, I've been running off the same install for the last couple/few years. I keep my system clean (hardware/software) and it runs everything fine... However, when it's been on for 8-10+ hours I notice that YouTube video becomes slightly laggy.. and i get frame rate drops in game.. So I started using the frame rate command in BF4 to monitor this, I play 1440p maxed out and get 70-80fps, I'll notice that every 5-6 seconds the frame rate drops by almost half for a single frame then returns. I get the same issue regardless of the game/app running. I've looked at the Task Manager whilst gaming to see what could be hogging resources and nothing jumps out at me. It's been like this for a while now and a simple reboot solves the issue. I reboot then load back into the game and it's like butter. My rig is running 4 monitors (3x22" 1080p 1x28" 1440p) my system is stable and for the last 6+ months it's been running at stock. I have a slight OC on my Titan (resetting to default doesnt fix) and have the lasted drivers and updates installed. I've tried CCleaner to clear out the REG (after so many years running the same install I thought for sure this would be the problem) and ran other apps to clear temp files and the like. Yet it still becomes laggy after prolonged use. My temps are great too, I'm totally at a loss as to whats causing this. Any ideas? SPECS: Hardware- Silverstone ST1000 1KW PSU Asus Maximus IV Gene-Z GEN3 MOBO Intel i7 2600k @4.5ghz Asus GeForce GTX Titan Asus Xoner DX2 2x 4GB SAMSUNG GREEN DDR3 @1866mhz OCZ Agility 3 240gb SSD (Games) Plextor M5 Pro 256gb (Windows) Seagate 3TB Barracuda (Data) J.